ACTIVITIES OF THE SUMMER PARTY OF THE 44TH JAPANESE ANTARCTIC RESEARCH EXPEDITION, MARINE SCIENCE CRUISE 2003

Activities of the summer party of the 44th Japanese Antarctic Research Expedition, Marine Science Cruise 2003

The summer activities of the 44th Japanese Antarctic Research Expedition (JARE-44) in 2002-2003 on board the Antarctic research vessel Shirase and at and around Syowa Station, Antarctica are reported.JARE-44 members on board the Shirase included forty members of the wintering party and seventeen members of the summer party.The summer party and wint

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Hemophilia A subjects with an intron-22 gene inversion mutation show CD4+ T-effector responses to multiple epitopes in FVIII

BackgroundAlmost half of severe hemophilia A (HA) is caused by an intron 22 inversion mutation (Int22Inv), which disrupts the 26-exon F8 gene.Inverted F8 mRNA exons 1-22 are transcribed, while F8B mRNA, containing F8 exons Step Up Pulley Assembly 23-26, is transcribed from a promoter within intron 22.Neither FVIII activity nor FVIII antigen (cross-

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